Edaravone and Acetovanillone Upregulate Nrf2 and PI3K/Akt/mTOR Signaling and Prevent Cyclophosphamide Cardiotoxicity in Rats

INTRODUCTION: Cyclophosphamide (CP) causes redox imbalance and its use is associated with marked cardiotoxicity that limits its clinical applications. The present study investigated the protective effects of acetovanillone (AV) and edaravone (ED) against CP-induced oxidative stress and cardiac damag...

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Detalles Bibliográficos
Autores principales: Hassanein, Emad H M, Abd El-Ghafar, Omnia A M, Ahmed, Marwa A, Sayed, Ahmed M, Gad-Elrab, Wail M, Ajarem, Jamaan S, Allam, Ahmed A, Mahmoud, Ayman M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721127/
https://www.ncbi.nlm.nih.gov/pubmed/33299300
http://dx.doi.org/10.2147/DDDT.S281854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721127/
https://www.ncbi.nlm.nih.gov/pubmed/33299300
http://dx.doi.org/10.2147/DDDT.S281854

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