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Edaravone and Acetovanillone Upregulate Nrf2 and PI3K/Akt/mTOR Signaling and Prevent Cyclophosphamide Cardiotoxicity in Rats
INTRODUCTION: Cyclophosphamide (CP) causes redox imbalance and its use is associated with marked cardiotoxicity that limits its clinical applications. The present study investigated the protective effects of acetovanillone (AV) and edaravone (ED) against CP-induced oxidative stress and cardiac damag...
Autores principales: | Hassanein, Emad H M, Abd El-Ghafar, Omnia A M, Ahmed, Marwa A, Sayed, Ahmed M, Gad-Elrab, Wail M, Ajarem, Jamaan S, Allam, Ahmed A, Mahmoud, Ayman M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721127/ https://www.ncbi.nlm.nih.gov/pubmed/33299300 http://dx.doi.org/10.2147/DDDT.S281854 |
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