α-MSH-PE38KDEL Kills Melanoma Cells via Modulating Erk1/2/MITF/TYR Signaling in an MC1R-Dependent Manner

BACKGROUND/OBJECTIVE: The immunotoxin α-MSH-PE38KDEL consisting of α-MSH and PE38KDEL showed high cytotoxicity on MSH receptor-positive melanoma cells, suggesting that α-MSH-PE38KDEL might be a potent drug for the treatment of melanoma. Herein, we explored whether the Erk1/2/MITF/TYR signaling, a ve...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Xilin, Li, Hong, Cong, Xianling, Huo, Da, Cong, Lele, Wu, Guangzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721307/
https://www.ncbi.nlm.nih.gov/pubmed/33299329
http://dx.doi.org/10.2147/OTT.S268554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721307/
https://www.ncbi.nlm.nih.gov/pubmed/33299329
http://dx.doi.org/10.2147/OTT.S268554

Ejemplares similares