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α-MSH-PE38KDEL Kills Melanoma Cells via Modulating Erk1/2/MITF/TYR Signaling in an MC1R-Dependent Manner

BACKGROUND/OBJECTIVE: The immunotoxin α-MSH-PE38KDEL consisting of α-MSH and PE38KDEL showed high cytotoxicity on MSH receptor-positive melanoma cells, suggesting that α-MSH-PE38KDEL might be a potent drug for the treatment of melanoma. Herein, we explored whether the Erk1/2/MITF/TYR signaling, a ve...

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Detalles Bibliográficos
Autores principales:	Liu, Xilin, Li, Hong, Cong, Xianling, Huo, Da, Cong, Lele, Wu, Guangzhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721307/ https://www.ncbi.nlm.nih.gov/pubmed/33299329 http://dx.doi.org/10.2147/OTT.S268554

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