Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis

A series of 5,8-disubstituted tetrahydroisoquinolines were shown to be effective inhibitors of M. tb in culture and modest inhibitors of M. tb ATP synthase. There was a broad general trend of improved potency with higher lipophilicity. Large substituents (e.g., Bn) at the tetrahydroquinoline 5-posit...

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Detalles Bibliográficos
Autores principales: Lu, Guo-Liang, Tong, Amy S.T., Conole, Daniel, Sutherland, Hamish S., Choi, Peter J., Franzblau, Scott G., Upton, Anna M., Lotlikar, Manisha U., Cooper, Christopher B., Denny, William A., Palmer, Brian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721589/
https://www.ncbi.nlm.nih.gov/pubmed/33007562
http://dx.doi.org/10.1016/j.bmc.2020.115784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721589/
https://www.ncbi.nlm.nih.gov/pubmed/33007562
http://dx.doi.org/10.1016/j.bmc.2020.115784

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