2-methoxyestradiol sensitizes breast cancer cells to taxanes by targeting centrosomes

Centrosomes amplification is a hallmark of cancer. We hypothesize that 2-methoxyestradiol (2-ME) sensitizes breast cancer (BC) cells to taxanes by targeting amplified centrosomes. We assessed the extent by which 2-ME together with paclitaxel (PTX) induces centrosome alterations with subsequent mitot...

Descripción completa

Detalles Bibliográficos
Autores principales: El-Zein, Randa, Thaiparambil, Jose, Abdel-Rahman, Sherif Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721614/
https://www.ncbi.nlm.nih.gov/pubmed/33400733
http://dx.doi.org/10.18632/oncotarget.27810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721614/
https://www.ncbi.nlm.nih.gov/pubmed/33400733
http://dx.doi.org/10.18632/oncotarget.27810

Ejemplares similares