Population-Matched Transcriptome Prediction Increases TWAS Discovery and Replication Rate

Most genome-wide association studies (GWAS) and transcriptome-wide association studies (TWAS) focus on European populations; however, these results cannot always be accurately applied to non-European populations due to genetic architecture differences. Using GWAS summary statistics in the Population...

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Detalles Bibliográficos
Autores principales: Geoffroy, Elyse, Gregga, Isabelle, Wheeler, Heather E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721644/
https://www.ncbi.nlm.nih.gov/pubmed/33313492
http://dx.doi.org/10.1016/j.isci.2020.101850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721644/
https://www.ncbi.nlm.nih.gov/pubmed/33313492
http://dx.doi.org/10.1016/j.isci.2020.101850

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