Cargando…

Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia

The bioactive vitamin D(3), 1α,25(OH)(2)D(3), plays a central role in calcium homeostasis by controlling the activity of the vitamin D receptor (VDR) in various tissues. Hypercalcemia secondary to high circulating levels of vitamin D(3) leads to hypercalciuria, nephrocalcinosis and renal dysfunction...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rovito, Daniela, Belorusova, Anna Y., Chalhoub, Sandra, Rerra, Anna-Isavella, Guiot, Elvire, Molin, Arnaud, Linglart, Agnès, Rochel, Natacha, Laverny, Gilles, Metzger, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721737/ https://www.ncbi.nlm.nih.gov/pubmed/33288743 http://dx.doi.org/10.1038/s41467-020-20069-4

Ejemplares similares

Vitamin D Analogs Bearing C-20 Modifications Stabilize the Agonistic Conformation of Non-Responsive Vitamin D Receptor Variants
por: Belorusova, Anna Y., et al.
Publicado: (2022)

Single-cell analyses unravel cell type–specific responses to a vitamin D analog in prostatic precancerous lesions
por: Abu el Maaty, Mohamed A., et al.
Publicado: (2021)

Carborane-based design of a potent vitamin D receptor agonist
por: Otero, Rocio, et al.
Publicado: (2016)

Vitamin D and Its Receptor from a Structural Perspective
por: Rochel, Natacha
Publicado: (2022)

1α,20S-Dihydroxyvitamin D(3) Interacts with Vitamin D Receptor: Crystal Structure and Route of Chemical Synthesis
por: Lin, Zongtao, et al.
Publicado: (2017)

Molecular determinants of MED1 interaction with the DNA bound VDR–RXR heterodimer
por: Belorusova, Anna Y, et al.
Publicado: (2020)

Severe hypercalcemia unmasked by Vitamin D in a patient with sarcoidosis
por: Nayak-Rao, S
Publicado: (2013)

Vitamin D poisoning; hypercalcemia in a case with richter transformation
por: Biberoğlu, Serap, et al.
Publicado: (2021)

An Unusual Case of Hypercalcemia Associated with Graves’ Disease and Vitamin D Deficiency
por: Korytnaya, Evgenia, et al.
Publicado: (2011)

MON-338 1-25 Vitamin D-Mediated Hypercalcemia of Malignancy
por: Maier, Sheila, et al.
Publicado: (2019)

Falsely Elevated 25-Hydroxy-Vitamin D Levels in Patients with Hypercalcemia
por: Choi, Moon Kyung, et al.
Publicado: (2020)

SAT-510 Hypercalcemia Secondary to Vitamin D Intoxication and Nephrocalcinosis in 2 Children
por: Diaz, Alejandro, et al.
Publicado: (2019)

LBODP020 Treatment Of Hypercalcemia Due To Prolonged, Excessive Vitamin D Intake
por: Abdelrahman, Houda, et al.
Publicado: (2022)

Androgen receptor coordinates muscle metabolic and contractile functions
por: Ghaibour, Kamar, et al.
Publicado: (2023)

Myod1 and GR coordinate myofiber-specific transcriptional enhancers
por: Rovito, Daniela, et al.
Publicado: (2021)

1α,25(OH)(2)-3-Epi-Vitamin D(3), a Natural Physiological Metabolite of Vitamin D(3): Its Synthesis, Biological Activity and Crystal Structure with Its Receptor
por: Molnár, Ferdinand, et al.
Publicado: (2011)

Vitamin D toxicity presenting as hypercalcemia and complete heart block: An interesting case report
por: Garg, G, et al.
Publicado: (2012)

Comparison of Treatment Regimens in Management of Severe Hypercalcemia Due to Vitamin D Intoxication in Children
por: Demir, Korcan, et al.
Publicado: (2019)

SAT246 Ectopic (Penile) Calcification in 1, 25 Vitamin D Induced Hypercalcemia
por: Berquist, John, et al.
Publicado: (2023)

Reduction in Hypercalcemia Following Readjustment of Target Serum 25-Hydroxy Vitamin D Concentration during Cholecalciferol Therapy in Vitamin D-Deficient Critically Ill Patients
por: Dickerson, Roland N., et al.
Publicado: (2022)

Hypercalcemia worsened after vitamin D supplementation in a sarcoidosis patient: A case report
por: Mio, Kimito, et al.
Publicado: (2022)

A Nonsecosteroidal Vitamin D Receptor Modulator Ameliorates Experimental Autoimmune Encephalomyelitis without Causing Hypercalcemia
por: Na, Songqing, et al.
Publicado: (2011)

Identification of Novel Non-secosteroidal Vitamin D Receptor Agonists with Potent Cardioprotective Effects and devoid of Hypercalcemia
por: Khedkar, Santosh A., et al.
Publicado: (2017)

Demonstrative Experiment on the Favorable Effects of Static Electric Field Treatment on Vitamin D(3)-Induced Hypercalcemia
por: Kimura, Tohru, et al.
Publicado: (2021)

Childhood Hypercalciuric Hypercalcemia With Elevated Vitamin D and Suppressed Parathyroid Hormone: Long-Term Follow Up
por: Gurevich, Evgenia, et al.
Publicado: (2021)

Case Report: Severe Hypercalcemia Following Vitamin D Intoxication in an Infant, the Underestimated Danger of Dietary Supplements
por: Gérard, Alexandre O., et al.
Publicado: (2022)

SAT240 Recurrent Hypercalcemia Due To 1,25 Dihydroxy Vitamin D Elevation Of Unclear Etiology
por: Javvaji, Abhiram, et al.
Publicado: (2023)

Design, Synthesis, Evaluation and Structure of Allenic 1α,25‐Dihydroxyvitamin D(3) Analogs with Locked Mobility at C‐17
por: Fraga, Ramón, et al.
Publicado: (2021)

ODP096 Hypercalcemia Secondary to Vitamin D Supplementation with Normal 25-Hydroxyvitamin D Level in an Elderly Female - Case Report
por: Arora, Gunjan, et al.
Publicado: (2022)

Vitamin D: The “sunshine” vitamin
por: Nair, Rathish, et al.
Publicado: (2012)

ODP079 BCG-Osis, a Rare Cause of 1,25 Hydroxy Vitamin D Mediated Hypercalcemia
por: Azim, Sidra, et al.
Publicado: (2022)

Cytosolic Sequestration of Prep1 Influences Early Stages of T Cell Development
por: Penkov, Dmitry, et al.
Publicado: (2008)

Vitamin D and Vitamin D3 Supplementation during Photodynamic Therapy: A Review
por: Mazur, Anna, et al.
Publicado: (2022)

Vitamin D Binding Protein and Vitamin D Levels
por: Xie, Zhongjian, et al.
Publicado: (2014)

Vitamin D, vitamin D receptor and tissue barriers
por: Zhang, Yong-guo, et al.
Publicado: (2013)

Vitamin D and urological cancers
por: Krajewski, Wojciech, et al.
Publicado: (2016)

The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease
por: Lv, Lingling, et al.
Publicado: (2020)

SAT260 Asymptomatic Vitamin A Toxicity Causing Hypercalcemia
por: Seshan, Nandini, et al.
Publicado: (2023)

Vitamin D
por: Tangpricha, Vin, et al.
Publicado: (2010)

Investigation of 20S-hydroxyvitamin D(3) analogs and their 1α-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities
por: Lin, Zongtao, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_hjcrh8koq25hkhhu5vnaqktnds