Quantifying the influence of mutation detection on tumour subclonal reconstruction

Whole-genome sequencing can be used to estimate subclonal populations in tumours and this intra-tumoural heterogeneity is linked to clinical outcomes. Many algorithms have been developed for subclonal reconstruction, but their variabilities and consistencies are largely unknown. We evaluate sixteen...

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Detalles Bibliográficos
Autores principales: Liu, Lydia Y., Bhandari, Vinayak, Salcedo, Adriana, Espiritu, Shadrielle M. G., Morris, Quaid D., Kislinger, Thomas, Boutros, Paul C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721877/
https://www.ncbi.nlm.nih.gov/pubmed/33288765
http://dx.doi.org/10.1038/s41467-020-20055-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721877/
https://www.ncbi.nlm.nih.gov/pubmed/33288765
http://dx.doi.org/10.1038/s41467-020-20055-w

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