Differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice
A recreational drug, 3,4‐methylenedioxymethamphetamine (MDMA), has prosocial effects including increased sociability, enhancement of trust feelings, and empathy. Although several methods, such as the social interaction and three chamber tests, have been used, the neural mechanisms underlying the pro...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722663/ https://www.ncbi.nlm.nih.gov/pubmed/32608059 http://dx.doi.org/10.1002/npr2.12124 |
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author | Mukai, Satoko Nakada, Sao Kamada, Hikari Yaguchi, Ryuma Deyama, Satoshi Kaneda, Katsuyuki |
author_facet | Mukai, Satoko Nakada, Sao Kamada, Hikari Yaguchi, Ryuma Deyama, Satoshi Kaneda, Katsuyuki |
author_sort | Mukai, Satoko |
collection | PubMed |
description | A recreational drug, 3,4‐methylenedioxymethamphetamine (MDMA), has prosocial effects including increased sociability, enhancement of trust feelings, and empathy. Although several methods, such as the social interaction and three chamber tests, have been used, the neural mechanisms underlying the prosocial effects have not been well understood. In the present study, based on a social approach paradigm using a single‐chamber apparatus, we have developed two reproducible and simple social approach tests, SAT1 and SAT2, in ICR mice. In the SAT1, an unfamiliar mouse was set in a wire mesh cylinder cage that was placed in the center of a rectangular open field, while in the SAT2, an unfamiliar mouse was set in a wire mesh rectangular cage that was placed along a wall of a rectangular open field. Although MDMA treatment enhanced sociability in both SAT1 and SAT2, the ratio of high sociability mice was higher in the SAT2 than in the SAT1, indicating a differential sensitivity to detect the prosocial effects. Thus, we suggest that the SAT2 is a promising and suitable method to explore the neuronal mechanisms underlying the effects of MDMA. |
format | Online Article Text |
id | pubmed-7722663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77226632020-12-08 Differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice Mukai, Satoko Nakada, Sao Kamada, Hikari Yaguchi, Ryuma Deyama, Satoshi Kaneda, Katsuyuki Neuropsychopharmacol Rep Micro Reports A recreational drug, 3,4‐methylenedioxymethamphetamine (MDMA), has prosocial effects including increased sociability, enhancement of trust feelings, and empathy. Although several methods, such as the social interaction and three chamber tests, have been used, the neural mechanisms underlying the prosocial effects have not been well understood. In the present study, based on a social approach paradigm using a single‐chamber apparatus, we have developed two reproducible and simple social approach tests, SAT1 and SAT2, in ICR mice. In the SAT1, an unfamiliar mouse was set in a wire mesh cylinder cage that was placed in the center of a rectangular open field, while in the SAT2, an unfamiliar mouse was set in a wire mesh rectangular cage that was placed along a wall of a rectangular open field. Although MDMA treatment enhanced sociability in both SAT1 and SAT2, the ratio of high sociability mice was higher in the SAT2 than in the SAT1, indicating a differential sensitivity to detect the prosocial effects. Thus, we suggest that the SAT2 is a promising and suitable method to explore the neuronal mechanisms underlying the effects of MDMA. John Wiley and Sons Inc. 2020-06-30 /pmc/articles/PMC7722663/ /pubmed/32608059 http://dx.doi.org/10.1002/npr2.12124 Text en © 2020 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsycho Pharmacology This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Micro Reports Mukai, Satoko Nakada, Sao Kamada, Hikari Yaguchi, Ryuma Deyama, Satoshi Kaneda, Katsuyuki Differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice |
title | Differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice |
title_full | Differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice |
title_fullStr | Differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice |
title_full_unstemmed | Differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice |
title_short | Differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice |
title_sort | differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (mdma) in different social approach paradigms in mice |
topic | Micro Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722663/ https://www.ncbi.nlm.nih.gov/pubmed/32608059 http://dx.doi.org/10.1002/npr2.12124 |
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