Differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice

A recreational drug, 3,4‐methylenedioxymethamphetamine (MDMA), has prosocial effects including increased sociability, enhancement of trust feelings, and empathy. Although several methods, such as the social interaction and three chamber tests, have been used, the neural mechanisms underlying the pro...

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Autores principales: Mukai, Satoko, Nakada, Sao, Kamada, Hikari, Yaguchi, Ryuma, Deyama, Satoshi, Kaneda, Katsuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722663/
https://www.ncbi.nlm.nih.gov/pubmed/32608059
http://dx.doi.org/10.1002/npr2.12124
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author Mukai, Satoko
Nakada, Sao
Kamada, Hikari
Yaguchi, Ryuma
Deyama, Satoshi
Kaneda, Katsuyuki
author_facet Mukai, Satoko
Nakada, Sao
Kamada, Hikari
Yaguchi, Ryuma
Deyama, Satoshi
Kaneda, Katsuyuki
author_sort Mukai, Satoko
collection PubMed
description A recreational drug, 3,4‐methylenedioxymethamphetamine (MDMA), has prosocial effects including increased sociability, enhancement of trust feelings, and empathy. Although several methods, such as the social interaction and three chamber tests, have been used, the neural mechanisms underlying the prosocial effects have not been well understood. In the present study, based on a social approach paradigm using a single‐chamber apparatus, we have developed two reproducible and simple social approach tests, SAT1 and SAT2, in ICR mice. In the SAT1, an unfamiliar mouse was set in a wire mesh cylinder cage that was placed in the center of a rectangular open field, while in the SAT2, an unfamiliar mouse was set in a wire mesh rectangular cage that was placed along a wall of a rectangular open field. Although MDMA treatment enhanced sociability in both SAT1 and SAT2, the ratio of high sociability mice was higher in the SAT2 than in the SAT1, indicating a differential sensitivity to detect the prosocial effects. Thus, we suggest that the SAT2 is a promising and suitable method to explore the neuronal mechanisms underlying the effects of MDMA.
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spelling pubmed-77226632020-12-08 Differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice Mukai, Satoko Nakada, Sao Kamada, Hikari Yaguchi, Ryuma Deyama, Satoshi Kaneda, Katsuyuki Neuropsychopharmacol Rep Micro Reports A recreational drug, 3,4‐methylenedioxymethamphetamine (MDMA), has prosocial effects including increased sociability, enhancement of trust feelings, and empathy. Although several methods, such as the social interaction and three chamber tests, have been used, the neural mechanisms underlying the prosocial effects have not been well understood. In the present study, based on a social approach paradigm using a single‐chamber apparatus, we have developed two reproducible and simple social approach tests, SAT1 and SAT2, in ICR mice. In the SAT1, an unfamiliar mouse was set in a wire mesh cylinder cage that was placed in the center of a rectangular open field, while in the SAT2, an unfamiliar mouse was set in a wire mesh rectangular cage that was placed along a wall of a rectangular open field. Although MDMA treatment enhanced sociability in both SAT1 and SAT2, the ratio of high sociability mice was higher in the SAT2 than in the SAT1, indicating a differential sensitivity to detect the prosocial effects. Thus, we suggest that the SAT2 is a promising and suitable method to explore the neuronal mechanisms underlying the effects of MDMA. John Wiley and Sons Inc. 2020-06-30 /pmc/articles/PMC7722663/ /pubmed/32608059 http://dx.doi.org/10.1002/npr2.12124 Text en © 2020 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsycho Pharmacology This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Micro Reports
Mukai, Satoko
Nakada, Sao
Kamada, Hikari
Yaguchi, Ryuma
Deyama, Satoshi
Kaneda, Katsuyuki
Differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice
title Differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice
title_full Differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice
title_fullStr Differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice
title_full_unstemmed Differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice
title_short Differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice
title_sort differential sensitivity to detect prosocial effects of 3,4‐methylenedioxymethamphetamine (mdma) in different social approach paradigms in mice
topic Micro Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722663/
https://www.ncbi.nlm.nih.gov/pubmed/32608059
http://dx.doi.org/10.1002/npr2.12124
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