Prefrontal cortex infusion of beta‐hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant‐like effects in a rodent model of depression

AIMS: Neuroinflammation is deeply related to the pathophysiology of depression. Beta‐hydroxybutyrate (BHB), which is an endogenous ketone body, exerts anti‐inflammatory effects, and peripheral administration of BHB induces antidepressant effects in an animal model of depression; however, it is uncle...

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Detalles Bibliográficos
Autores principales: Kajitani, Naofumi, Iwata, Masaaki, Miura, Akihiko, Tsunetomi, Kyohei, Yamanashi, Takehiko, Matsuo, Ryoichi, Nishiguchi, Tsuyoshi, Fukuda, Saki, Nagata, Mayu, Shibushita, Midori, Yamauchi, Takahira, Pu, Shenghong, Shirayama, Yukihiko, Watanabe, Ken, Kaneko, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722664/
https://www.ncbi.nlm.nih.gov/pubmed/32125791
http://dx.doi.org/10.1002/npr2.12099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722664/
https://www.ncbi.nlm.nih.gov/pubmed/32125791
http://dx.doi.org/10.1002/npr2.12099

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