Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4

The cyclin-dependent kinase inhibitor p27(Kip1) is a tumor suppressor whose intrinsic activity in cancer cells correlates with tumor aggressiveness, invasiveness, and impaired tumor cell differentiation. Here we explore whether p27(Kip1) indirectly influences tumor progression by restricting expansi...

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Detalles Bibliográficos
Autores principales: Choi, Sung Hee, Barker, Emily C., Gerber, Kyle J., Letterio, John J., Kim, Byung-Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722707/
https://www.ncbi.nlm.nih.gov/pubmed/33329939
http://dx.doi.org/10.1080/2162402X.2020.1847832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722707/
https://www.ncbi.nlm.nih.gov/pubmed/33329939
http://dx.doi.org/10.1080/2162402X.2020.1847832

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