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Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4
The cyclin-dependent kinase inhibitor p27(Kip1) is a tumor suppressor whose intrinsic activity in cancer cells correlates with tumor aggressiveness, invasiveness, and impaired tumor cell differentiation. Here we explore whether p27(Kip1) indirectly influences tumor progression by restricting expansi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722707/ https://www.ncbi.nlm.nih.gov/pubmed/33329939 http://dx.doi.org/10.1080/2162402X.2020.1847832 |