Protection from α-Synuclein induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20

Dopaminergic neurons of the substantia nigra are selectively vulnerable to mitochondrial dysfunction, which is hypothesized to be an early and fundamental pathogenic mechanism in Parkinson’s disease (PD). Mitochondrial function depends on the successful import of nuclear-encoded proteins, many of wh...

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Detalles Bibliográficos
Autores principales: De Miranda, Briana R., Rocha, Emily M., Castro, Sandra L., Greenamyre, J. Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722884/
https://www.ncbi.nlm.nih.gov/pubmed/33293540
http://dx.doi.org/10.1038/s41531-020-00139-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722884/
https://www.ncbi.nlm.nih.gov/pubmed/33293540
http://dx.doi.org/10.1038/s41531-020-00139-6

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