Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier

BACKGROUND: Inter-individual differences in dihydropyrimidine dehydrogenase (DPYD encoding DPD) and thiopurine S-methyltransferase (TPMT) activity are important predictors for fluoropyrimidine and thiopurine toxicity. While several variants in these genes are known to decrease enzyme activities, man...

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Detalles Bibliográficos
Autores principales: Zhou, Yitian, Dagli Hernandez, Carolina, Lauschke, Volker M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722893/
https://www.ncbi.nlm.nih.gov/pubmed/32973300
http://dx.doi.org/10.1038/s41416-020-01084-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722893/
https://www.ncbi.nlm.nih.gov/pubmed/32973300
http://dx.doi.org/10.1038/s41416-020-01084-0

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