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Myonuclear content regulates cell size with similar scaling properties in mice and humans

Muscle fibers are the largest cells in the body, and one of its few syncytia. Individual cell sizes are variable and adaptable, but what governs cell size has been unclear. We find that muscle fibers are DNA scarce compared to other cells, and that the nuclear number (N) adheres to the relationship...

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Detalles Bibliográficos
Autores principales: Hansson, Kenth-Arne, Eftestøl, Einar, Bruusgaard, Jo C., Juvkam, Inga, Cramer, Alyssa W., Malthe-Sørenssen, Anders, Millay, Douglas P., Gundersen, Kristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722898/
https://www.ncbi.nlm.nih.gov/pubmed/33293572
http://dx.doi.org/10.1038/s41467-020-20057-8