B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms

The molecular and cellular mechanisms mediating thymic central tolerance and prevention of autoimmunity are not fully understood. Here we show that B7-CD28 co-stimulation and B7 expression by specific antigen-presenting cell (APC) types are required for clonal deletion and for regulatory T (Treg) ce...

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Detalles Bibliográficos
Autores principales: Watanabe, Masashi, Lu, Ying, Breen, Michael, Hodes, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722925/
https://www.ncbi.nlm.nih.gov/pubmed/33293517
http://dx.doi.org/10.1038/s41467-020-20070-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722925/
https://www.ncbi.nlm.nih.gov/pubmed/33293517
http://dx.doi.org/10.1038/s41467-020-20070-x

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