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Zinc and SARS-CoV-2: A molecular modeling study of Zn interactions with RNA-dependent RNA-polymerase and 3C-like proteinase enzymes

RNA-dependent RNA-polymerase (RdRp) and 3C-like proteinase (3CL(pro)) are two main enzymes that play a key role in the replication of SARS-CoV-2. Zinc (Zn) has strong immunogenic properties and is known to bind to a number of proteins, modulating their activities. Zn also has a history of use in vir...

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Detalles Bibliográficos
Autores principales: Pormohammad, Ali, Monych, Nadia K., Turner, Raymond J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723401/
https://www.ncbi.nlm.nih.gov/pubmed/33236142
http://dx.doi.org/10.3892/ijmm.2020.4790