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Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation
The calcium release-activated calcium channel Orai regulates Ca(2+) entry into non-excitable cells and is required for proper immune function. While the channel typically opens following Ca(2+) release from the endoplasmic reticulum, certain pathologic mutations render the channel constitutively ope...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723414/ https://www.ncbi.nlm.nih.gov/pubmed/33252040 http://dx.doi.org/10.7554/eLife.62772 |