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Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation

The calcium release-activated calcium channel Orai regulates Ca(2+) entry into non-excitable cells and is required for proper immune function. While the channel typically opens following Ca(2+) release from the endoplasmic reticulum, certain pathologic mutations render the channel constitutively ope...

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Detalles Bibliográficos
Autores principales:	Hou, Xiaowei, Outhwaite, Ian R, Pedi, Leanne, Long, Stephen Barstow
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723414/ https://www.ncbi.nlm.nih.gov/pubmed/33252040 http://dx.doi.org/10.7554/eLife.62772

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