Expression of Oncolytic Adenovirus-Encoded RNAi Molecules Is Most Effective in a pri-miRNA Precursor Format

Oncolytic adenoviruses are being developed as new anti-cancer agents. Their efficacy can be improved by incorporating RNA interference (RNAi) molecules. RNAi molecules can be expressed in various precursor formats. The aim of this study was to determine the most effective format. To this end, we con...

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Detalles Bibliográficos
Autores principales: Brachtlova, Tereza, van Ginkel, Jan-Willem, Luinenburg, Mark J., de Menezes, Renée X., Koppers-Lalic, Danijela, Pegtel, D. Michiel, Dong, Wenliang, de Gruijl, Tanja D., van Beusechem, Victor W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723779/
https://www.ncbi.nlm.nih.gov/pubmed/33335978
http://dx.doi.org/10.1016/j.omto.2020.10.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723779/
https://www.ncbi.nlm.nih.gov/pubmed/33335978
http://dx.doi.org/10.1016/j.omto.2020.10.012

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