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Expression of Oncolytic Adenovirus-Encoded RNAi Molecules Is Most Effective in a pri-miRNA Precursor Format
Oncolytic adenoviruses are being developed as new anti-cancer agents. Their efficacy can be improved by incorporating RNA interference (RNAi) molecules. RNAi molecules can be expressed in various precursor formats. The aim of this study was to determine the most effective format. To this end, we con...
Autores principales: | Brachtlova, Tereza, van Ginkel, Jan-Willem, Luinenburg, Mark J., de Menezes, Renée X., Koppers-Lalic, Danijela, Pegtel, D. Michiel, Dong, Wenliang, de Gruijl, Tanja D., van Beusechem, Victor W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723779/ https://www.ncbi.nlm.nih.gov/pubmed/33335978 http://dx.doi.org/10.1016/j.omto.2020.10.012 |
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