Antibody Isotype Switching as a Mechanism to Counter HIV Neutralization Escape

Neutralizing antibodies (nAbs) to highly variable viral pathogens show remarkable diversification during infection, resulting in an “arms race” between virus and host. Studies of nAb lineages have shown how somatic hypermutation (SHM) in immunoglobulin (Ig)-variable regions enables maturing antibodi...

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Detalles Bibliográficos
Autores principales: Scheepers, Cathrine, Bekker, Valerie, Anthony, Colin, Richardson, Simone I., Oosthuysen, Brent, Moyo, Thandeka, Kgagudi, Prudence, Kitchin, Dale, Nonyane, Molati, York, Talita, Mielke, Dieter, Mabvakure, Batsirai M., Sheng, Zizhang, Lambson, Bronwen E., Ismail, Arshad, Garrett, Nigel J., Karim, Salim S. Abdool, Shapiro, Lawrence, Williamson, Carolyn, Morris, Lynn, Moore, Penny L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723817/
https://www.ncbi.nlm.nih.gov/pubmed/33238131
http://dx.doi.org/10.1016/j.celrep.2020.108430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723817/
https://www.ncbi.nlm.nih.gov/pubmed/33238131
http://dx.doi.org/10.1016/j.celrep.2020.108430

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