Chronic traumatic encephalopathy—a blueprint for the bridge between neurological and psychiatric disorders

Chronic traumatic encephalopathy (CTE) is a perplexing condition characterized by a broad and diverse range of neuropathology and psychopathology. While there are no agreed upon or validated clinical criteria for CTE, case series of CTE have described a wide range of neuropsychiatric symptoms that h...

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Autores principales: Albayram, Onder, Albayram, Sait, Mannix, Rebekkah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723988/
https://www.ncbi.nlm.nih.gov/pubmed/33293571
http://dx.doi.org/10.1038/s41398-020-01111-x
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author Albayram, Onder
Albayram, Sait
Mannix, Rebekkah
author_facet Albayram, Onder
Albayram, Sait
Mannix, Rebekkah
author_sort Albayram, Onder
collection PubMed
description Chronic traumatic encephalopathy (CTE) is a perplexing condition characterized by a broad and diverse range of neuropathology and psychopathology. While there are no agreed upon or validated clinical criteria for CTE, case series of CTE have described a wide range of neuropsychiatric symptoms that have been attributed to repetitive traumatic brain injuries (rTBI). However, the direct links between the psychopathology of psychiatric and neurological conditions from rTBI to CTE remains poorly understood. Prior studies suggest that repetitive cerebral injuries are associated with damage to neural circuitry involved in emotional and memory processes, but these studies do not offer longitudinal assessments that prove causation. More recent studies on novel targets, such as transmission of misfolded proteins, as well as newly advanced non-invasive imaging techniques may offer more direct evidence of the pathogenesis of CTE by tracing the progression of pathology and display of related behavioral impairments. Understanding this interface in the context of rTBI can play an important role in future approaches to the definition, assessment, prevention, and treatment of CTE and mental illnesses.
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spelling pubmed-77239882020-12-17 Chronic traumatic encephalopathy—a blueprint for the bridge between neurological and psychiatric disorders Albayram, Onder Albayram, Sait Mannix, Rebekkah Transl Psychiatry Review Article Chronic traumatic encephalopathy (CTE) is a perplexing condition characterized by a broad and diverse range of neuropathology and psychopathology. While there are no agreed upon or validated clinical criteria for CTE, case series of CTE have described a wide range of neuropsychiatric symptoms that have been attributed to repetitive traumatic brain injuries (rTBI). However, the direct links between the psychopathology of psychiatric and neurological conditions from rTBI to CTE remains poorly understood. Prior studies suggest that repetitive cerebral injuries are associated with damage to neural circuitry involved in emotional and memory processes, but these studies do not offer longitudinal assessments that prove causation. More recent studies on novel targets, such as transmission of misfolded proteins, as well as newly advanced non-invasive imaging techniques may offer more direct evidence of the pathogenesis of CTE by tracing the progression of pathology and display of related behavioral impairments. Understanding this interface in the context of rTBI can play an important role in future approaches to the definition, assessment, prevention, and treatment of CTE and mental illnesses. Nature Publishing Group UK 2020-12-08 /pmc/articles/PMC7723988/ /pubmed/33293571 http://dx.doi.org/10.1038/s41398-020-01111-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Albayram, Onder
Albayram, Sait
Mannix, Rebekkah
Chronic traumatic encephalopathy—a blueprint for the bridge between neurological and psychiatric disorders
title Chronic traumatic encephalopathy—a blueprint for the bridge between neurological and psychiatric disorders
title_full Chronic traumatic encephalopathy—a blueprint for the bridge between neurological and psychiatric disorders
title_fullStr Chronic traumatic encephalopathy—a blueprint for the bridge between neurological and psychiatric disorders
title_full_unstemmed Chronic traumatic encephalopathy—a blueprint for the bridge between neurological and psychiatric disorders
title_short Chronic traumatic encephalopathy—a blueprint for the bridge between neurological and psychiatric disorders
title_sort chronic traumatic encephalopathy—a blueprint for the bridge between neurological and psychiatric disorders
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723988/
https://www.ncbi.nlm.nih.gov/pubmed/33293571
http://dx.doi.org/10.1038/s41398-020-01111-x
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