Population genomics of East Asian ethnic groups

East Asia constitutes one-fifth of the global population and exhibits substantial genetic diversity. However, genetic investigations on populations in this region have been largely under-represented compared with European populations. Nonetheless, the last decade has seen considerable efforts and pr...

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Autores principales: Pan, Ziqing, Xu, Shuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724877/
https://www.ncbi.nlm.nih.gov/pubmed/33292737
http://dx.doi.org/10.1186/s41065-020-00162-w
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author Pan, Ziqing
Xu, Shuhua
author_facet Pan, Ziqing
Xu, Shuhua
author_sort Pan, Ziqing
collection PubMed
description East Asia constitutes one-fifth of the global population and exhibits substantial genetic diversity. However, genetic investigations on populations in this region have been largely under-represented compared with European populations. Nonetheless, the last decade has seen considerable efforts and progress in genome-wide genotyping and whole-genome sequencing of the East-Asian ethnic groups. Here, we review the recent studies in terms of ancestral origin, population relationship, genetic differentiation, and admixture of major East- Asian groups, such as the Chinese, Korean, and Japanese populations. We mainly focus on insights from the whole-genome sequence data and also include the recent progress based on mitochondrial DNA (mtDNA) and Y chromosome data. We further discuss the evolutionary forces driving genetic diversity in East-Asian populations, and provide our perspectives for future directions on population genetics studies, particularly on underrepresented indigenous groups in East Asia.
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spelling pubmed-77248772020-12-09 Population genomics of East Asian ethnic groups Pan, Ziqing Xu, Shuhua Hereditas Review East Asia constitutes one-fifth of the global population and exhibits substantial genetic diversity. However, genetic investigations on populations in this region have been largely under-represented compared with European populations. Nonetheless, the last decade has seen considerable efforts and progress in genome-wide genotyping and whole-genome sequencing of the East-Asian ethnic groups. Here, we review the recent studies in terms of ancestral origin, population relationship, genetic differentiation, and admixture of major East- Asian groups, such as the Chinese, Korean, and Japanese populations. We mainly focus on insights from the whole-genome sequence data and also include the recent progress based on mitochondrial DNA (mtDNA) and Y chromosome data. We further discuss the evolutionary forces driving genetic diversity in East-Asian populations, and provide our perspectives for future directions on population genetics studies, particularly on underrepresented indigenous groups in East Asia. BioMed Central 2020-12-08 /pmc/articles/PMC7724877/ /pubmed/33292737 http://dx.doi.org/10.1186/s41065-020-00162-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Pan, Ziqing
Xu, Shuhua
Population genomics of East Asian ethnic groups
title Population genomics of East Asian ethnic groups
title_full Population genomics of East Asian ethnic groups
title_fullStr Population genomics of East Asian ethnic groups
title_full_unstemmed Population genomics of East Asian ethnic groups
title_short Population genomics of East Asian ethnic groups
title_sort population genomics of east asian ethnic groups
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724877/
https://www.ncbi.nlm.nih.gov/pubmed/33292737
http://dx.doi.org/10.1186/s41065-020-00162-w
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