Exploration into the origins and mobilization of di-hydrofolate reductase genes and the emergence of clinical resistance to trimethoprim

Trimethoprim is a synthetic antibacterial agent that targets folate biosynthesis by competitively binding to the di-hydrofolate reductase enzyme (DHFR). Trimethoprim is often administered synergistically with sulfonamide, another chemotherapeutic agent targeting the di-hydropteroate synthase (DHPS)...

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Detalles Bibliográficos
Autores principales: Sánchez-Osuna, Miquel, Cortés, Pilar, Llagostera, Montserrat, Barbé, Jordi, Erill, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725336/
https://www.ncbi.nlm.nih.gov/pubmed/32969787
http://dx.doi.org/10.1099/mgen.0.000440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725336/
https://www.ncbi.nlm.nih.gov/pubmed/32969787
http://dx.doi.org/10.1099/mgen.0.000440

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