Free energy calculations of the functional selectivity of 5-HT(2B) G protein-coupled receptor

G Protein-Coupled Receptors (GPCRs) mediate intracellular signaling in response to extracellular ligand binding and are the target of one-third of approved drugs. Ligand binding modulates the GPCR molecular free energy landscape by preferentially stabilizing active or inactive conformations that dic...

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Detalles Bibliográficos
Autores principales: Peters, Brandon L., Deng, Jinxia, Ferguson, Andrew L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725398/
https://www.ncbi.nlm.nih.gov/pubmed/33296400
http://dx.doi.org/10.1371/journal.pone.0243313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725398/
https://www.ncbi.nlm.nih.gov/pubmed/33296400
http://dx.doi.org/10.1371/journal.pone.0243313

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