RNA polymerase II CTD S2P is dispensable for embryogenesis but mediates exit from developmental diapause in C. elegans

Serine 2 phosphorylation (S2P) within the CTD of RNA polymerase II is considered a Cdk9/Cdk12-dependent mark required for 3′-end processing. However, the relevance of CTD S2P in metazoan development is unknown. We show that cdk-12 lesions or a full-length CTD S2A substitution results in an identical...

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Detalles Bibliográficos
Autores principales: Cassart, C., Yague-Sanz, C., Bauer, F., Ponsard, P., Stubbe, F. X., Migeot, V., Wery, M., Morillon, A., Palladino, F., Robert, V., Hermand, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725455/
https://www.ncbi.nlm.nih.gov/pubmed/33298437
http://dx.doi.org/10.1126/sciadv.abc1450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725455/
https://www.ncbi.nlm.nih.gov/pubmed/33298437
http://dx.doi.org/10.1126/sciadv.abc1450

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