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RNA polymerase II CTD S2P is dispensable for embryogenesis but mediates exit from developmental diapause in C. elegans
Serine 2 phosphorylation (S2P) within the CTD of RNA polymerase II is considered a Cdk9/Cdk12-dependent mark required for 3′-end processing. However, the relevance of CTD S2P in metazoan development is unknown. We show that cdk-12 lesions or a full-length CTD S2A substitution results in an identical...
Autores principales: | Cassart, C., Yague-Sanz, C., Bauer, F., Ponsard, P., Stubbe, F. X., Migeot, V., Wery, M., Morillon, A., Palladino, F., Robert, V., Hermand, D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725455/ https://www.ncbi.nlm.nih.gov/pubmed/33298437 http://dx.doi.org/10.1126/sciadv.abc1450 |
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