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The Hippo pathway coactivator Yorkie can reprogram cell fates and create compartment-boundary–like interactions at clone margins

During development, tissue-specific patterns of gene expression are established by transcription factors and then stably maintained via epigenetic mechanisms. Cancer cells often express genes that are inappropriate for that tissue or developmental stage. Here, we show that high activity levels of Yk...

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Detalles Bibliográficos
Autores principales: Bairzin, Joanna C. D., Emmons-Bell, Maya, Hariharan, Iswar K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725458/
https://www.ncbi.nlm.nih.gov/pubmed/33298454
http://dx.doi.org/10.1126/sciadv.abe8159