Mus81-Eme1–dependent aberrant processing of DNA replication intermediates in mitosis impairs genome integrity

Chromosome instability (CIN) underpins cancer evolution and is associated with drug resistance and poor prognosis. Understanding the mechanistic basis of CIN is thus a priority. The structure-specific endonuclease Mus81-Eme1 is known to prevent CIN. Intriguingly, however, here we show that the aberr...

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Detalles Bibliográficos
Autores principales: Calzetta, Nicolás Luis, Besteiro, Marina Alejandra González, Gottifredi, Vanesa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725468/
https://www.ncbi.nlm.nih.gov/pubmed/33298441
http://dx.doi.org/10.1126/sciadv.abc8257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725468/
https://www.ncbi.nlm.nih.gov/pubmed/33298441
http://dx.doi.org/10.1126/sciadv.abc8257

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