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Mus81-Eme1–dependent aberrant processing of DNA replication intermediates in mitosis impairs genome integrity
Chromosome instability (CIN) underpins cancer evolution and is associated with drug resistance and poor prognosis. Understanding the mechanistic basis of CIN is thus a priority. The structure-specific endonuclease Mus81-Eme1 is known to prevent CIN. Intriguingly, however, here we show that the aberr...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725468/ https://www.ncbi.nlm.nih.gov/pubmed/33298441 http://dx.doi.org/10.1126/sciadv.abc8257 |