Evolved bacterial resistance against fluoropyrimidines can lower chemotherapy impact in the Caenorhabditis elegans host

Metabolism of host-targeted drugs by the microbiome can substantially impact host treatment success. However, since many host-targeted drugs inadvertently hamper microbiome growth, repeated drug administration can lead to microbiome evolutionary adaptation. We tested if evolved bacterial resistance...

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Detalles Bibliográficos
Autores principales: Rosener, Brittany, Sayin, Serkan, Oluoch, Peter O, García González, Aurian P, Mori, Hirotada, Walhout, Albertha JM, Mitchell, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725501/
https://www.ncbi.nlm.nih.gov/pubmed/33252330
http://dx.doi.org/10.7554/eLife.59831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725501/
https://www.ncbi.nlm.nih.gov/pubmed/33252330
http://dx.doi.org/10.7554/eLife.59831

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