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Improvement of muscular atrophy by AAV–SaCas9-mediated myostatin gene editing in aged mice
Muscle mass and area usually decrease with age, and this phenomenon is known as sarcopenia. This age-related atrophy correlates with insufficient levels of muscle cells differentiate and proliferate regulated by the TGF-β signaling pathway and the expression of E3s ubiquitin-protein ligase by the ag...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725670/ https://www.ncbi.nlm.nih.gov/pubmed/32398787 http://dx.doi.org/10.1038/s41417-020-0178-7 |