Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering

Statins induce plaque regression characterized by reduced macrophage content in humans, but the underlying mechanisms remain speculative. Studying the translational APOE*3-Leiden.CETP mouse model with a humanized lipoprotein metabolism, we find that systemic cholesterol lowering by oral atorvastatin...

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Detalles Bibliográficos
Autores principales: Härdtner, Carmen, Kornemann, Jan, Krebs, Katja, Ehlert, Carolin A., Jander, Alina, Zou, Jiadai, Starz, Christopher, Rauterberg, Simon, Sharipova, Diana, Dufner, Bianca, Hoppe, Natalie, Dederichs, Tsai-Sang, Willecke, Florian, Stachon, Peter, Heidt, Timo, Wolf, Dennis, von zur Mühlen, Constantin, Madl, Josef, Kohl, Peter, Kaeser, Rafael, Boettler, Tobias, Pieterman, Elsbeth J., Princen, Hans M. G., Ho-Tin-Noé, Benoît, Swirski, Filip K., Robbins, Clinton S., Bode, Christoph, Zirlik, Andreas, Hilgendorf, Ingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725697/
https://www.ncbi.nlm.nih.gov/pubmed/33296022
http://dx.doi.org/10.1007/s00395-020-00838-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725697/
https://www.ncbi.nlm.nih.gov/pubmed/33296022
http://dx.doi.org/10.1007/s00395-020-00838-4

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