Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans

Transgenes are prone to progressive silencing due to their structure, copy number, and genomic location. In C. elegans, repressive mechanisms are particularly strong in the germline with almost fully penetrant transgene silencing in simple extrachromosomal arrays and frequent silencing of single-cop...

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Detalles Bibliográficos
Autores principales: Aljohani, Mohammed D., El Mouridi, Sonia, Priyadarshini, Monika, Vargas-Velazquez, Amhed M., Frøkjær-Jensen, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725773/
https://www.ncbi.nlm.nih.gov/pubmed/33298957
http://dx.doi.org/10.1038/s41467-020-19898-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725773/
https://www.ncbi.nlm.nih.gov/pubmed/33298957
http://dx.doi.org/10.1038/s41467-020-19898-0

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