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Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans
Transgenes are prone to progressive silencing due to their structure, copy number, and genomic location. In C. elegans, repressive mechanisms are particularly strong in the germline with almost fully penetrant transgene silencing in simple extrachromosomal arrays and frequent silencing of single-cop...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725773/ https://www.ncbi.nlm.nih.gov/pubmed/33298957 http://dx.doi.org/10.1038/s41467-020-19898-0 |