Cargando…
Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production
The development of targeted drugs for the treatment of cancer remains an unmet medical need. This study was designed to investigate the mechanism underlying breast cancer cell growth suppression caused by fused isoselenazolium salts. The ability to suppress the proliferation of malignant and normal...
Autores principales: | Makrecka-Kuka, Marina, Dimitrijevs, Pavels, Domracheva, Ilona, Jaudzems, Kristaps, Dambrova, Maija, Arsenyan, Pavel |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725824/ https://www.ncbi.nlm.nih.gov/pubmed/33299068 http://dx.doi.org/10.1038/s41598-020-78620-8 |
Ejemplares similares
-
Olaparib Conjugates with Selenopheno[3,2-c]quinolinone Inhibit PARP1 and Reverse ABCB1-Related Multidrug Resistance
por: Makrecka-Kuka, Marina, et al.
Publicado: (2022) -
Inhibition of CPT2 exacerbates cardiac dysfunction and inflammation in experimental endotoxaemia
por: Makrecka‐Kuka, Marina, et al.
Publicado: (2020) -
Pharmacological activation of PPARβ/δ preserves mitochondrial respiratory function in ischemia/reperfusion via stimulation of fatty acid oxidation-linked respiration and PGC-1α/NRF-1 signaling
por: Papatheodorou, Ioanna, et al.
Publicado: (2022) -
Microbiota-Derived Metabolite Trimethylamine N-Oxide Protects Mitochondrial Energy Metabolism and Cardiac Functionality in a Rat Model of Right Ventricle Heart Failure
por: Videja, Melita, et al.
Publicado: (2021) -
Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice
por: Kuka, Janis, et al.
Publicado: (2020)