Structural and biochemical analyses of an aminoglycoside 2′-N-acetyltransferase from Mycolicibacterium smegmatis

The expression of aminoglycoside-modifying enzymes represents a survival strategy of antibiotic-resistant bacteria. Aminoglycoside 2′-N-acetyltransferase [AAC(2′)] neutralizes aminoglycoside drugs by acetylation of their 2′ amino groups in an acetyl coenzyme A (CoA)-dependent manner. To understand t...

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Detalles Bibliográficos
Autores principales: Jeong, Chang-Sook, Hwang, Jisub, Do, Hackwon, Cha, Sun-Shin, Oh, Tae-Jin, Kim, Hak Jun, Park, Hyun Ho, Lee, Jun Hyuck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725843/
https://www.ncbi.nlm.nih.gov/pubmed/33299080
http://dx.doi.org/10.1038/s41598-020-78699-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725843/
https://www.ncbi.nlm.nih.gov/pubmed/33299080
http://dx.doi.org/10.1038/s41598-020-78699-z

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