Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster

Degradation of polychlorinated biphenyls (PCBs) is initiated by cytochrome P450 (CYP) enzymes and includes PCB oxidation to OH-metabolites, which often display a higher toxicity than their parental compounds. In search of an animal model reflecting PCB metabolism and toxicity, we tested Drosophila m...

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Detalles Bibliográficos
Autores principales: Idda, T., Bonas, C., Hoffmann, J., Bertram, J., Quinete, N., Schettgen, T., Fietkau, K., Esser, A., Stope, M. B., Leijs, M. M., Baron, J. M., Kraus, T., Voigt, A., Ziegler, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726022/
https://www.ncbi.nlm.nih.gov/pubmed/33299007
http://dx.doi.org/10.1038/s41598-020-78405-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726022/
https://www.ncbi.nlm.nih.gov/pubmed/33299007
http://dx.doi.org/10.1038/s41598-020-78405-z

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