Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases

Histone lysine methyltransferases (KMTs) play an important role in epigenetic gene regulation and have emerged as promising targets for drug discovery. However, the scope and limitation of KMT catalysis on substrates possessing substituted lysine side chains remain insufficiently explored. Here, we...

Descripción completa

Detalles Bibliográficos
Autores principales: Al Temimi, Abbas H. K., Merx, Jona, van Noortwijk, Christian J., Proietti, Giordano, Buijs, Romano, White, Paul B., Rutjes, Floris P. J. T., Boltje, Thomas J., Mecinović, Jasmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726145/
https://www.ncbi.nlm.nih.gov/pubmed/33299050
http://dx.doi.org/10.1038/s41598-020-78331-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726145/
https://www.ncbi.nlm.nih.gov/pubmed/33299050
http://dx.doi.org/10.1038/s41598-020-78331-0

Ejemplares similares