Discovery of 5,5′-Methylenedi-2,3-Cresotic Acid as a Potent Inhibitor of the Chemotactic Activity of the HMGB1·CXCL12 Heterocomplex Using Virtual Screening and NMR Validation

HMGB1 is a key molecule that both triggers and sustains inflammation following infection or injury, and is involved in a large number of pathologies, including cancer. HMGB1 participates in the recruitment of inflammatory cells, forming a heterocomplex with the chemokine CXCL12 (HMGB1·CXCL12), there...

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Detalles Bibliográficos
Autores principales: De Leo, Federica, Quilici, Giacomo, De Marchis, Francesco, Mantonico, Malisa Vittoria, Bianchi, Marco Emilio, Musco, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726319/
https://www.ncbi.nlm.nih.gov/pubmed/33324614
http://dx.doi.org/10.3389/fchem.2020.598710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726319/
https://www.ncbi.nlm.nih.gov/pubmed/33324614
http://dx.doi.org/10.3389/fchem.2020.598710

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