PMO-based let-7c site blocking oligonucleotide (SBO) mediated utrophin upregulation in mdx mice, a therapeutic approach for Duchenne muscular dystrophy (DMD)

Upregulation of utrophin, a dystrophin related protein, is considered a promising therapeutic approach for Duchenne muscular dystrophy (DMD). Utrophin expression is repressed at the post-transcriptional level by a set of miRNAs, among which let-7c is evolutionarily highly conserved. We designed PMO-...

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Detalles Bibliográficos
Autores principales: Sengupta, Kasturi, Loro, Emanuele, Khurana, Tejvir S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726560/
https://www.ncbi.nlm.nih.gov/pubmed/33298994
http://dx.doi.org/10.1038/s41598-020-76338-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726560/
https://www.ncbi.nlm.nih.gov/pubmed/33298994
http://dx.doi.org/10.1038/s41598-020-76338-1

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