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Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling

Combined fatty acid esterification and lipolysis, termed lipid cycling, is an ATP‐consuming process that contributes to energy expenditure. Therefore, interventions that stimulate energy expenditure through lipid cycling are of great interest. Here we find that pharmacological and genetic inhibition...

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Detalles Bibliográficos
Autores principales: Veliova, Michaela, Ferreira, Caroline M, Benador, Ilan Y, Jones, Anthony E, Mahdaviani, Kiana, Brownstein, Alexandra J, Desousa, Brandon R, Acín‐Pérez, Rebeca, Petcherski, Anton, Assali, Essam A, Stiles, Linsey, Divakaruni, Ajit S, Prentki, Marc, Corkey, Barbara E, Liesa, Marc, Oliveira, Marcus F, Shirihai, Orian S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726774/
https://www.ncbi.nlm.nih.gov/pubmed/33275313
http://dx.doi.org/10.15252/embr.201949634