Structure-Based Scaffold Repurposing toward the Discovery of Novel Cholinesterase Inhibitors

[Image: see text] Cholinesterases (ChE) are well-known drug targets for the treatment of Alzheimer’s disease (AD). In continuation of work to develop novel cholinesterase inhibitors, we utilized a structure-based scaffold repurposing approach and discovered six novel ChE inhibitors from our recently...

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Detalles Bibliográficos
Autores principales: Dighe, Satish N., Tippana, Mangapathiraju, van Akker, Suzannah, Collet, Trudi A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726787/
https://www.ncbi.nlm.nih.gov/pubmed/33324805
http://dx.doi.org/10.1021/acsomega.0c03848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726787/
https://www.ncbi.nlm.nih.gov/pubmed/33324805
http://dx.doi.org/10.1021/acsomega.0c03848

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