Pharmacological targeting of KDM6A and KDM6B, as a novel therapeutic strategy for treating craniosynostosis in Saethre-Chotzen syndrome

BACKGROUND: During development, excessive osteogenic differentiation of mesenchymal progenitor cells (MPC) within the cranial sutures can lead to premature suture fusion or craniosynostosis, leading to craniofacial and cognitive issues. Saethre-Chotzen syndrome (SCS) is a common form of craniosynost...

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Detalles Bibliográficos
Autores principales: Pribadi, Clara, Camp, Esther, Cakouros, Dimitrios, Anderson, Peter, Glackin, Carlotta, Gronthos, Stan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726873/
https://www.ncbi.nlm.nih.gov/pubmed/33298158
http://dx.doi.org/10.1186/s13287-020-02051-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726873/
https://www.ncbi.nlm.nih.gov/pubmed/33298158
http://dx.doi.org/10.1186/s13287-020-02051-5

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