A bispecific T cell engager targeting Glypican-1 redirects T cell cytolytic activity to kill prostate cancer cells

BACKGROUND: Glypican-1 is a heparan sulfate proteoglycan that is overexpressed in prostate cancer (PCa), and a variety of solid tumors. Importantly, expression is restricted in normal tissue, making it an ideal tumor targeting antigen. Since there is clinical and preclinical evidence of the efficacy...

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Detalles Bibliográficos
Autores principales: Lund, Maria E., Howard, Christopher B., Thurecht, Kristofer J., Campbell, Douglas H., Mahler, Stephen M., Walsh, Bradley J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727117/
https://www.ncbi.nlm.nih.gov/pubmed/33302918
http://dx.doi.org/10.1186/s12885-020-07562-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727117/
https://www.ncbi.nlm.nih.gov/pubmed/33302918
http://dx.doi.org/10.1186/s12885-020-07562-1

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