Berberine reduces temozolomide resistance by inducing autophagy via the ERK1/2 signaling pathway in glioblastoma

BACKGROUND: The ability to treat glioblastoma (GBM) using the chemotherapeutic agent temozolomide (TMZ) has been hampered by the development of therapeutic resistance. In this study, we assessed the ability of the isoquinoline alkaloid berberine to alter GBM TMZ resistance using two different TMZ-re...

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Detalles Bibliográficos
Autores principales: Qu, Huiling, Song, Xiaofu, Song, Zhuyin, Jiang, Xin, Gao, Xin, Bai, Lijuan, Wu, Jiao, Na, Li, Yao, Zhicheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727240/
https://www.ncbi.nlm.nih.gov/pubmed/33298057
http://dx.doi.org/10.1186/s12935-020-01693-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727240/
https://www.ncbi.nlm.nih.gov/pubmed/33298057
http://dx.doi.org/10.1186/s12935-020-01693-y

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