A systematic evaluation of the design and context dependencies of massively parallel reporter assays

Massively parallel reporter assays (MPRAs) functionally screen thousands of sequences for regulatory activity in parallel. To date, there has been no systematic comparison of differences in MPRA design. Here, we screen a library of 2,440 candidate liver enhancers and controls for regulatory activity...

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Detalles Bibliográficos
Autores principales: Klein, Jason C., Agarwal, Vikram, Inoue, Fumitaka, Keith, Aidan, Martin, Beth, Kircher, Martin, Ahituv, Nadav, Shendure, Jay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727316/
https://www.ncbi.nlm.nih.gov/pubmed/33046894
http://dx.doi.org/10.1038/s41592-020-0965-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727316/
https://www.ncbi.nlm.nih.gov/pubmed/33046894
http://dx.doi.org/10.1038/s41592-020-0965-y

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