Recalibration of mapping quality scores in Illumina short-read alignments improves SNP detection results in low-coverage sequencing data

BACKGROUND: Low-coverage sequencing is a cost-effective way to obtain reads spanning an entire genome. However, read depth at each locus is low, making sequencing error difficult to separate from actual variation. Prior to variant calling, sequencer reads are aligned to a reference genome, with alig...

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Detalles Bibliográficos
Autores principales: Cline, Eliot, Wisittipanit, Nuttachat, Boongoen, Tossapon, Chukeatirote, Ekachai, Struss, Darush, Eungwanichayapant, Anant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727374/
https://www.ncbi.nlm.nih.gov/pubmed/33354434
http://dx.doi.org/10.7717/peerj.10501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727374/
https://www.ncbi.nlm.nih.gov/pubmed/33354434
http://dx.doi.org/10.7717/peerj.10501

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